Schisandrone

SKU: orb1684949

Description

Schisandrone (Arisantetralone C) is a 4-aryltetralone lignan isolated from Schisandra chinensis fruit. It is utilized in research for its potential neuroprotective and hepatoprotective activities, as investigated in various in vitro and in vivo experimental models.

Research Area

Immunology & Inflammation, Neuroscience, Signal Transduction

Key Properties

• CAS Number: 98619-25-1
• MW: 356.41
• Purity: 99.84% (May vary between batches)
• Formula: C₂₁H₂₄O₅
• SMILES: C[C@H]1[C@@H](C=2C(C(=O)[C@H]1C)=CC(O)=C(OC)C2)C3=CC(OC)=C(OC)C=C3
• Target: NF-κB|||Beta Amyloid|||NOS

Bioactivity

• In Vitro:
  To explore the effect of Schisandrone on tau protein phosphorylation in the process of differentiation of APP transgenic mouse neural stem cells into neural cells. Compared with the APP+ cell control group, cell fluorescence intensity became weak in the Schisandrone group. Phosphorylation levels of Tau[Ps262] and Tau[Ps396] were reduced, especially at Tau[Ps396] site. Phosphorylation levels of Tau[Ps262] and Tau[Ps396] were low in the APP- cell control group.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NF-kB, NFkB, NFκB, NF-κB, NOS, BetaAmyloid, Beta Amyloid, bAmyloid, Arisantetralone C, b Amyloid, Schisandrone, β Amyloid, βAmyloid

Compound Identifiers

PubChem CID

14078177