Schisandrin C

SKU: orb1301269

Description

Schisandrin C (Wuweizisu C) is a dibenzocyclooctadiene lignan isolated from Schisandra chinensis. It has demonstrated anticancer activity in vitro, such as inducing apoptosis in human leukemia U937 cells, and is a compound of interest for oncology and cell biology research.

Research Area

Cell Biology, Infectious Disease & Virology

Key Properties

• CAS Number: 61301-33-5
• MW: 384.42
• Purity: 99.44% (May vary between batches)
• Formula: C₂₂H₂₄O₆
• SMILES: C[C@@H]1CC2=CC3=C(OCO3)C(OC)=C2C4=C(OC)C5=C(OCO5)C=C4C[C@@H]1C
• Target: Apoptosis,Virus Protease
• Solubility: DMSO:25 mg/mL (65.03 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:0.5 mg/mL (1.3 mM)

Bioactivity

• In Vitro:
  Schisandrin C inhibited cell growth in a dose-dependent manner, which was associated with the induction of G1 arrest of the cell cycle and apoptosis. Schisandrin C induced G1 arrest was correlated with down-regulation of cyclin D1, cyclin E, cyclin-dependent kinase (Cdk) 4 and E2Fs expression, inhibition of phosphorylation of retinoblastoma protein (pRB), and up-regulation of the Cdk inhibitor p21(WAF1/CIP1). In addition, schisandrin C-induced apoptosis was associated with down-regulation of expression of the anti-apoptotic proteins Bcl-2 and Bcl-xL, proteolytic activation of caspase-3 and -9, and a concomitant degradation of poly(ADP-ribose) polymerase (PARP). Furthermore, schisandrin C-induced apoptosis was significantly inhibited by a caspase-3 specific inhibitor z-DEVD-fmk . Schisandrin C was found to reduce nitric oxide (NO) production from LPS-stimulated Raw 264.7 cells. Pre-treatment of Raw 264.7 cells with gomisin J, gomisin N, or schisandrin C reduced the expression of mRNA and the secretion of pro-inflammatory cytokines .

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

VirusProtease, Virus Protease, Schisandrin C, Schizandrin-C, Wuweizisu-C, Inhibitor, inhibit, lignan, liver disease, Apoptosis, antioxidant, anti-inflammatory, cancer, alzheimer's disease

Compound Identifiers

PubChem CID

119112