Schinifoline

SKU: orb1684918

Description

Schinifoline

Research Area

Cell Biology

Key Properties

• CAS Number: 80554-58-1
• MW: 257.37
• Purity: 99.79%
• Formula: C₁₇H₂₃NO
• SMILES: CN1C=2C(C(=O)C=C1CCCCCCC)=CC=CC2
• Target: Cell Cycle Arrest,Apoptosis

Bioactivity

• In Vitro:
  This work aimed to investigat the radiosensitizing effect of Schinifoline (SF) on A549 cells the cell viability results indicated cytotoxicity of SF on A549 cells, with IC50 Values of 33.7 ± 2.4, 21.9 ± 1.9 and 16.8 ± 2.2 μg/ml, respectively after 6, 12, 24 h treatment with different concentration , an the 10% or 20% IC50 concentration during 12 h was applied in later experiments the results of cell Proliferative Inhibition and clonogenic assay showed that SF enhance the radiosensitivity of A549 cells when applied before 60Co γ-irradiation and this effect was mainly time and concentration dependent the flow cytometric data indicated that SF treatment befor the irradiation increase the G2/M phase, thus improvin the radiosensitivity of A549, leading to cell apoptosis

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Schinifoline, cellcyclearrest, cell cycle arrest, Apoptosis

Compound Identifiers

PubChem CID

133504