SCH529074

SKU: orb1693218

Description

SCH529074

Research Area

Cell Biology

Key Properties

• CAS Number: 922150-11-6
• MW: 563.56
• Purity: 99.57% (May vary between batches)
• Formula: C₃₁H₃₆Cl₂N₆
• SMILES: CN(C)CCCNc1nc(CN2CCN(CC2)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)nc2ccccc12
• Target: p53,MDM-2/p53
• Solubility: DMF:33 mg/mL (58.56 mM);Ethanol:33 mg/mL (58.56 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.77 mM);DMSO:22.5 mg/mL (39.92 mM)

Bioactivity

• Target IC50:
  p53 DBD:1-2 μM (Ki)
• In Vivo:
  In female nude mice, 5–7 weeks of age, received subcutaneous inoculation of DLD-1 human colorectal carcinoma cells, SCH529074 (orally; 30 and 50 mg/kg) reduces 79 and 43% of tumor growth with the plasma exposure of 0.26–0.55 μm at 30 mg/kg and 0.39-0.79 μm at 50 mg/kg.
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• In Vitro:
  SCH529074 (2-4 µM) reduces cell viability and decreases to 20-25% in p53 mutant cells including H157, H1975, and H322, and to 68% in the p53 WT cell line A549 at 4 µM. SCH 529074 (2-4 µM) induces NSCLC cells including H157, A549, HCT116, and HCT116 p53-/- arrested at the G0/G1 phase (59%; 72%; 66%; and 57%).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SCH529074, SCH-529074, SCH 529074, p53

Compound Identifiers

PubChem CID

12001922