SCH-900875

SKU: orb3027441

Description

SCH-900875 is an orally active, brain-penetrant, and selective inhibitor of the CXCR3 receptor, demonstrating significant selectivity towards CXCR1 and CXCR2 receptors as well. By binding to CXCR3, SCH-900875 blocks the ligands CXCL9, CXCL10, and CXCL11, thereby inhibiting downstream G protein and β-arrestin signaling pathways and reducing inflammation cell migration. This compound holds potential for research into autoimmune diseases (such as rheumatoid arthritis and multiple sclerosis) and inflammatory conditions (such as psoriasis and inflammatory bowel disease).

Research Area

Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 907206-98-8
• MW: 553.10
• Formula: C₂₈H₃₇ClN₈O₂
• SMILES: C(C)[C@@H]1N(C[C@@H](C)N(C1)C=2C(C)=NC(=CN2)C=3OC(NCC)=NN3)C4CCN(C(=O)C5=CC=C(Cl)C=C5)CC4
• Target: Arrestin,CXCR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Arrestin,CXCR