SCH-336

SKU: orb1702822

Description

SCH-336 is a potent, selective, and orally active CB2 receptor agonist (Ki 1.8 nM) with 100-fold selectivity over CB1. It demonstrates functional activity by inhibiting GTPγS binding, CB2-mediated cell migration in vitro, and attenuating leukocyte migration and pulmonary eosinophilia in murine models of delayed hypersensitivity and allergy.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 447459-51-0
• MW: 539.64
• Purity: 97.00% (May vary between batches)
• Formula: C₂₃H₂₅NO₈S₃
• SMILES: S(=O)(=O)(C1=C(S(=O)(=O)C2=CC=C(OC)C=C2)C=C(OC)C=C1)C3=CC=C([C@@H](NS(C)(=O)=O)C)C=C3
• Target: Cannabinoid Receptor
• Solubility: DMSO:90 mg/mL (166.78 mM)

Bioactivity

• Target IC50:
  CB2 (human):2nM(EC50)|CB2 (BaF3 cells):34nM|CB1 (human):200nM(EC50)
• In Vivo:
  In in vivo studies, when administered intraperitoneally (i.p.) at doses of 0.02-2.0 mg/kg, SCH 336 significantly inhibits leukocyte migration .
• In Vitro:
  SCH 336 (also known as Sch.336) exhibits competitive binding with [3H]CP55,940 to human CB2 receptors on Sf9 cell membranes, with a Ki value of 1.8 nM. It reduces GTPγS binding on membranes containing human CB2 receptors, with an EC50 of 2 nM. However, its potency decreases on membranes containing CB1 receptors, with an EC50 of 200 nM . Moreover, SCH 336 inhibits the migration of BaF3/CB2 cells towards 100 nM 2-AG, with an IC50 of 34 nM .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CB2, CannabinoidReceptor, Cannabinoid Receptor, SCH-225336, SCH 336, SCH336, SCH-336

Compound Identifiers

PubChem CID

10324989