SCH-23390 hydrochloride

SKU: orb1302912

Description

SCH-23390 hydrochloride

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 125941-87-9
• MW: 324.24
• Purity: 99.51%
• Formula: C₁₇H₁₉Cl₂NO
• SMILES: Cl.CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c1ccccc1
• Target: Dopamine Receptor,Potassium Channel,5-HT Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.17 mM);H2O:25 mg/mL (77.1 mM);DMSO:50 mg/mL (154.21 mM)

Bioactivity

• Target IC50:
  5-HT2C receptor:9.3 nM (Ki)|GIRK:268 nM|D5:0.3 nM|D1:0.2 nM
• In Vivo:
  In the rat, the repeated administration of SCH 23390 (0.05 mg/kg s.c., thrice daily for 21 days) enhances the steady-state density of dopamine D1 receptors in the striatum (+30%) and substantia nigra (+24%).
• In Vitro:
  SCH23390 blocks endogenous GIRK currents induced by either somatostatin or D3 dopamine receptors in AtT-20 cells (IC50=268 nM).SCH 23390 also shows high affinity (Ki=9.3 nM) at h5-HT2C sites.
• Animal Research:
  Rats are injected with SCH 23390(0, 1, or 10 μg/kg i.p.).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5HTReceptor, 5-HT Receptor, 5HT Receptor, D5, D1, DopamineReceptor, Dopamine Receptor, Dopamine, Potassium Channel, R-(+)-SCH23390 hydrochloride, PotassiumChannel, R-SCH 23390 Hydrochloride, R-SCH23390 Hydrochloride, R-SCH-23390 Hydrochloride, SCH-23390 Hydrochloride

Compound Identifiers

PubChem CID

11957535