SC99

SKU: orb1298688

Description

SC99 is a selective small molecule inhibitor that targets the JAK2-STAT3 signaling pathway, suppressing the expression of downstream genes. It demonstrates potent antiplatelet and antithrombotic activity, and has shown efficacy in preclinical models of multiple myeloma, supporting its use in hematological and cardiovascular research.

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 882290-02-0
• MW: 336.15
• Purity: 99.68% (May vary between batches)
• Formula: C₁₅H₈Cl₂FN₃O
• SMILES: Fc1ccc(N\N=C(/C#N)C(=O)c2ccc(Cl)cc2)cc1Cl
• Target: STAT,Apoptosis,JAK
• Solubility: DMSO:82 mg/mL (243.94 mM)

Bioactivity

• In Vitro:
  SC99 inhibited the phosphorylation of JAK2 and STAT3 in human platelets but had no effects on the phosphorylation of AKT, p65 or Src, all of which are involved in platelet activation. SC99 inhibited human platelet aggregation induced by collagen and thrombin in a dose-dependent manner. SC99 inhibited thrombin-induced P-selectin expression and fibrinogen binding to single platelets. Moreover, SC99 inhibited platelet spreading on fibrinogen and clot retraction mediated by outside-in signaling. SC99 inhibited platelet aggregation in mice but it did not significantly prolong the bleeding time. SC99 inhibited platelet activation and aggregation as a STAT3 inhibitor. This agent can be developed as a promising treatment for thrombotic disorders.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ERK, Inhibitor, inhibit, myeloma, multiple, JAK, Janus kinase, JAK2, mTOR, orally, OPM2, c-Src, Apoptosis, ATP-binding, anti-myeloma, anti-thrombotic, activation, aggregation, AKT, pocket, phosphorylation, platelet, STAT, STAT3, SC 99, SC99, SC-99

Compound Identifiers

PubChem CID

5896323