SC57666

SKU: orb1708570

Description

SC57666 is a potent and selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 26 nM, exhibiting no inhibition of COX-1. This selectivity makes it a valuable research tool for investigating COX-2-mediated processes in models of inflammation, pain, and cancer, both in vitro and in vivo.

Research Area

Immunology & Inflammation, Neuroscience

Key Properties

• CAS Number: 158959-32-1
• MW: 316.39
• Purity: 99.48% (May vary between batches)
• Formula: C₁₈H₁₇FO₂S
• SMILES: CS(=O)(=O)c1ccc(cc1)C1=C(CCC1)c1ccc(F)cc1
• Target: COX
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (10.43 mM);DMSO:90 mg/mL (284.46 mM)

Bioactivity

• Target IC50:
  COX-2:26 nM
• In Vivo:
  In the adjuvant-induced arthritis model, SC57666 exhibits oral activity with an ED50 of 1.7 mpk. When administered orally at a dose of 600 mpk, SC57666 does not cause gastric lesions in mice after 5 hours. Similarly, no intestinal damage is observed in rats after 72 hours when administered orally at a dose of 200 mpk .
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• In Vitro:
  SC57666 exhibits potent inhibition of COX2 (IC50 of 3.2±0.8 nM) in CHO cells stably transfected with human COX isozymes, showing a selectivity of 1000-fold or greater over COX1 (IC50=6000±1900 nM) .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

COX-2, SC 57666, SC57666, SC-57666

Compound Identifiers

PubChem CID

443373