SC-58125

SKU: orb1305662

Description

SC-58125 is a potent and selective COX-2 inhibitor (IC50 = 0.04 µM) with demonstrated anti-inflammatory, analgesic, and antitumor properties. Its efficacy has been validated in both cellular assays and animal models, supporting its use in oncology and inflammation research.

Research Area

Immunology & Inflammation, Neuroscience

Key Properties

• CAS Number: 162054-19-5
• MW: 384.35
• Purity: 99.81% (May vary between batches)
• Formula: C₁₇H₁₂F₄N₂O₂S
• SMILES: CS(=O)(=O)c1ccc(cc1)-n1nc(cc1-c1ccc(F)cc1)C(F)(F)F
• Target: COX
• Solubility: DMSO:9 mg/mL (23.42 mM)

Bioactivity

• Target IC50:
  COX-1 (human):>100 μM|COX-2:0.04 μM
• In Vitro:
  SC-58125 treatment on the growth of human colon carcinoma cells in nude mice. Delaying treatment by 2, 4, or 7 weeks following implantation of the carcinoma cells resulted in a significant inhibition of tumor growth. Furthermore, short-term (48 hours) treatment with SC-58125 was sufficient to attenuate tumor growth for up to 15 days. SC-58125 treatment did not alter the rate at which cells underwent apoptosis, but did result in a delayed progression through the cell cycle at the G(2)/M transition. Accordingly, p34(cdc2) protein levels and activity were decreased following SC-58125 treatment.SC-58125 primarily exerts a cytostatic effect in vivo, which is likely to be mediated through inhibition of progression through the G(2)/M phase of the cell cycle
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SC 58125, SC58125, SC-58125, inhibit, inflammatory, Inhibitor, edema, antitumor, cancer, COX, COX-2, Cyclooxygenase

Compound Identifiers

PubChem CID

115239