SC-514

SKU: orb1306443

Description

SC-514

Research Area

Cell Biology, Epigenetics & Chromatin, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 354812-17-2
• MW: 224.3
• Purity: 99.93%
• Formula: C₉H₈N₂OS₂
• SMILES: NC(=O)c1sc(cc1N)-c1ccsc1
• Target: CDK,IκB/IKK,Aurora Kinase,Serine Protease,p38 MAPK
• Solubility: DMSO:40 mg/mL (178.33 mM);Ethanol:2.2 mg/mL (9.81 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.92 mM)

Bioactivity

• Target IC50:
  AUR2:71 μM|CDK2A:61 μM|PRAK:75 μM|MSK:123 μM|IKKβ:11.2±4.7 μM
• In Vivo:
  In rheumatoid arthritis synovial fibroblasts (RASFs), SC-514 (100 μM) inhibits the phosphorylation and degradation of IκBα, while also preventing the translocation of p65 into the nucleus. In the presence of IL-1β-induced inflammation, SC-514 effectively suppresses the expression of NF-κB-dependent genes: IL-6 (IC50=20 μM), IL-8 (IC50=20 μM), and COX-2 (IC50=8 μM).
• In Vitro:
  In nude mice implanted with A375 or G361 tumors, daily treatment was administered with SC-514 (25 mg/kg).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AuroraKinase, Aurora Kinase, Aurora B, CDK2/CyclinA, GK 01140, GK01140, GK-01140, I kappa B kinase, Inhibitor, IkB, IkB/IKK, IKK, IKK2, inhibit, IκB, IκB kinase, SerineProtease, Serine Protease, PRAK, p38α, p38MAPK, p38 MAPK, SC 514, SC514, SC-514

Compound Identifiers

PubChem CID

2807869