SC-43

SKU: orb1298899

Description

SC-43 is an orally bioavailable small molecule agonist of SHP-1 (PTPN6). Its mechanism involves inhibiting STAT3 phosphorylation, leading to pro-apoptotic effects demonstrated in vitro and in vivo. This activity underpins its research utility in oncology and fibrotic disease studies.

Research Area

Cell Biology, Metabolism Research, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1400989-25-4
• MW: 431.8
• Purity: 99.26% (May vary between batches)
• Formula: C₂₁H₁₃ClF₃N₃O₂
• SMILES: FC(F)(F)c1cc(NC(=O)Nc2cccc(Oc3ccc(cc3)C#N)c2)ccc1Cl
• Target: STAT,Apoptosis,Phosphatase
• Solubility: DMSO:100 mg/mL (231.59 mM);10% DMSO+90% Corn Oil:3.3 mg/mL (7.64 mM)

Bioactivity

• In Vivo:
  In vivo assay revealed that SC-43 exhibited xenograft tumor growth inhibition, p-STAT3 reduction and SHP-1 activity elevation.
• In Vitro:
  SC-43, a sorafenib derivative.SC-43-induced apoptosis in cholangiocarcinoma (CCA) via a novel mechanism. Three CCA cell lines (HuCCT-1, KKU-100 and CGCCA) were treated with SC-43 to determine their sensitivity to SC-43-induced cell death and apoptosis. SC-43 activated SH2 domain-containing phosphatase 1 (SHP-1) activity, leading to p-STAT3 and downstream cyclin B1 and Cdc2 downregulation, which induced G2-M arrest and apoptotic cell death. Importantly, SC-43 augmented SHP-1 activity by direct binding to N-SH2 and relief of its autoinhibition. Deletion of the N-SH2 domain (dN1) or point mutation (D61A) of SHP-1 counteracted the effect of SC-43-induced SHP-1 phosphatase activation and antiproliferation ability in CCA cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-fibrotic, Apoptosis, apoptosis, anticancer, antiproliferative, caspase-3, PARP, orally, inhibit, Inhibitor, Phosphatase, SHP-1, p-STAT3, PTPN6, SC 43, SC43, SC-43, STAT, STAT3

Compound Identifiers

PubChem CID

70688629