SC-26196

SKU: orb1220107

Description

SC-26196 is an orally active inhibitor of Delta6 desaturase (D6D) with IC50 of 0.2 μM in a rat liver microsomal assay, with antiinflammatory properties. The FADS2 inhibitor SC26196 reduced PBMC, but not Jurkat cell, proliferation suggesting PUFA synthesis is involved in regulating mitosis in PBMCs.

Key Properties

• CAS Number: 218136-59-5
• MW: 423.55
• Purity: >98% (HPLC)
• Formula: C₂₇H₂₉N₅
• SMILES: C1CN(CCN1CCCC(C#N)(C2=CC=CC=C2)C3=CC=CC=C3)N=CC4=CN=CC=C4
• Target: D6D
• Solubility: DMSO:4mg/ml (9.44 Mm; Need ultrasonic)

Bioactivity

• In Vivo:
  SC-26196 (included in the diet at 0, 0.07, 0.21, or 0.7 mg/kg diet to achieve dosages of 0, 10, 30, and 100 mg/kg per day) causes a decrease in the calculated Δ6-desaturase index in both adipose tissue and liver. Feeding 100 mg SC-26196 per kg BW per day inhibits the Δ6-desaturase enzyme. Animal model: Male mice (12-or 15-week-old). Dosage: 0, 10, 30, and 100 mg/kg per day. Administration: Included in the diet at 0, 0.07, 0.21, or 0.7 mg/kg diet to achieve dosages of 0, 10, 30, and 100 mg/kg per day. Result: Caused a decrease in the calculated Δ6-desaturase index in both adipose tissue and liver.
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• In Vitro:
  SC-26196 (200 nM) inhibits proliferation of peripheral blood mononuclear cells (PBMCs), but Not Jurkat Cells. Cell Proliferation Assay Cell line: PBMCs and Jurkat cells. Concentration: 200 nM. Incubation time: 96 hours for PBMCs; 144 hours for Jurkat cells. Result: Treatment of PBMCs significantly decreased the proportion of cells that underwent division, the division index and proliferation index.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

D6D