SBP-5147

SKU: orb3210579

Description

SBP-5147 is an orally active ULK1/ULK2 inhibitor with an IC50 of 2 nM for ULK1 and 53 nM for ULK2. It inhibits the phosphorylation of Beclin-1 and Vps34, reduces autophagy flux, downregulates the expression of ATG13 and ATG101, upregulates MHC-I expression, induces caspase-dependent apoptosis, and decreases the survival rate of non-small cell lung cancer cells. SBP-5147 can be utilized in research related to non-small cell lung cancer.

Key Properties

• CAS Number: 1884222-37-0
• MW: 349.35
• Formula: C₁₇H₁₈F₃N₅
• SMILES: FC(F)(F)C1=CN=C(N=C1NC2CC2)NC3=CC=C4C(=C3)CCNC4
• Target: Autophagy,MHC,Apoptosis,Caspase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Autophagy,MHC,Apoptosis,Caspase