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SBI-115

SKU: orb1220406

Description

SBI-115 is an antagonist of TGR5. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5.

Images & Validation

Key Properties

CAS Number882366-16-7
MW340.78
Purity>98% (HPLC)
FormulaC14H13ClN2O4S
SMILESCCS(=O)(=O)c1ncc(Cl)c(C(=O)Oc2cccc(C)c2)n1
TargetGPCR19
SolubilityDMSO:150 mg/mL (440.17 mM)

Bioactivity

In Vitro
SBI-115 (100-200 μM, 24 hours) inhibits proliferation triggered by pre-treatment of cystic cholangiocytes with Taurolithocholic acid (TLCA) in shRNA-transfected ADPKD cholangiocytes. Cell Proliferation Assay Cell line: shRNA-transfected ADPKD cholangiocytes. Concentration: 100, 200 μM. Incubation time: 24 hours. Result: Inhibited proliferation (by 32-48%) triggered by pre-treatment of cystic cholangiocytes with TLCA.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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  • SBI-115 [orb1299827]

    99.78% (May vary between batches)

    882366-16-7

    340.78

    C14H13ClN2O4S

    50 mg, 100 mg, 1 ml x 10 mM (in DMSO), 5 mg, 10 mg, 25 mg
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Protocol Information

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