SBI-0206965

SKU: orb1306418

Description

SBI-0206965 is a selective, cell-permeable inhibitor of the autophagy-initiating kinase ULK1, with an IC50 of 108 nM, and also inhibits ULK2 (IC50 = 711 nM). This tool compound is widely used in vitro and in vivo to investigate the fundamental role of autophagy in cancer, neurodegenerative diseases, and metabolic disorders.

Research Area

Cell Biology

Key Properties

• CAS Number: 1884220-36-3
• MW: 489.32
• Purity: >98%
• Formula: C₂₁H₂₁BrN₄O₅
• SMILES: CNC(=O)c1ccccc1Oc1nc(Nc2cc(OC)c(OC)c(OC)c2)ncc1Br
• Target: Kinase
• Solubility: Soluble in DMSO (up to 30 mg/ml)

Bioactivity

• Target IC50:
  ULK2:711 nM|ULK1:108 nM
• In Vitro:
  In HEK293T transfected with WT or KI Myc-tagged ULK1 and WT Vps34, SBI-0206965 inhibits Ser249 phosphorylation of overexpressed Vps34 and Beclin1 Ser15 phosphorylation. SBI-0206965 suppresses autophagy induced by mTOR inhibition in A549 cells, and prevents ULK1-dependent cell survival in WT MEFs. In addition, SBI-0206965 also synergizes with mTOR inhibition to induce cancer cell death.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Unc-51 like kinase, ULK1, ULK, SBI 0206965, SBI0206965, SBI-0206965, Apoptosis, Autophagy, inhibit, Inhibitor

Compound Identifiers

PubChem CID

92044402