SB772077B

SKU: orb3173880

Description

SB772077B is a ROCK inhibitor with anti-inflammatory properties. It boosts aqueous humor outflow (OF) by inhibiting the RhoA/ROCK signaling pathway. This compound significantly reduces mRNA levels of β-catenin and protein levels of fibrosis markers such as vinculin, fibronectin, collagen1 A, and vimentin. Additionally, SB772077B exhibits vasodilatory effects, lowering both pulmonary arterial and systemic blood pressure. It is useful for research on glaucoma and pulmonary arterial hypertension.

Research Area

Cell Biology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 785774-34-7
• MW: 342.36
• Formula: C₁₅H₁₈N₈O₂
• SMILES: C(C)N1C=2C(N=C1C=3C(N)=NON3)=CN=CC2C(=O)N4CC[C@H](N)C4
• Target: ROCK,Wnt/beta-catenin

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

ROCK,Wnt/beta-catenin