SB399885

SKU: orb1306939

Description

SB399885 is a potent, selective, and orally bioavailable SR-6 receptor antagonist with high brain penetration. Its selectivity profile makes it a valuable research tool for investigating SR-6 receptor function in both in vitro assays and in vivo models of central nervous system disorders.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 402713-80-8
• MW: 446.35
• Purity: 98.94% (May vary between batches)
• Formula: C₁₈H₂₁Cl₂N₃O₄S
• SMILES: O(C)C1=C(C=C(S(NC2=C(OC)C(Cl)=CC(Cl)=C2)(=O)=O)C=C1)N3CCNCC3
• Target: 5-HT Receptor
• Solubility: DMSO:55 mg/mL (123.22 mM)

Bioactivity

• Target IC50:
  SR6 (human recombinant):9.11 (pKi)|SR6 (native human):9.02 (pKi)|SR6 (native rat):8.81 (pKi)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SB 399885, SB 399885 Hydrochloride, SB399885, SB-399885, SB399885 HCl, SB-399885 HCl, SB399885 Hydrochloride, SB-399885 Hydrochloride, 5-HT6, 5HT Receptor, 5HTReceptor

Compound Identifiers

PubChem CID

6918649