SB273005

SKU: orb1685632

Description

SB273005 is a potent, orally bioavailable small molecule antagonist of integrins αvβ3 and αvβ5. It has demonstrated in vivo efficacy in murine pregnancy models by suppressing Th2 cell differentiation and IL-10 cytokine production, supporting its research use in immunology and reproductive studies.

Research Area

Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 205678-31-5
• MW: 451.44
• Purity: 99.58% (May vary between batches)
• Formula: C₂₂H₂₄F₃N₃O₄
• SMILES: C(C(O)=O)[C@@H]1CC=2C(CN(CC(F)(F)F)C1=O)=CC(OCCC=3N=C(NC)C=CC3)=CC2
• Target: Interleukin,Integrin
• Solubility: Ethanol:10 mg/mL (22.15 mM);H2O:<1 mg/mL;DMSO:83 mg/mL (183.86 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.31 mM)

Bioactivity

• Target IC50:
  αvβ5 integrin:0.3 nM|αvβ3 integrin:1.2 nM
• In Vivo:
  In rat models of bone resorption and osteoporosis, SB273005 (30 mg/kg, p.o.) inhibits the parathyroid hormone-stimulated calcemic response, and inhibits bone loss. In rat with adjuvant-induced arthritis, SB273005 (60 mg/kg, p.o.) significantly reduces the symptoms of adjuvant-induced arthritis. SB273005 (1000 mg/kg/day, p.o.) causes acute, transient necrosis of vascular smooth muscle cell (VSMC) in aorta and renal arteries of mice. In pregnant mice, SB273005 reverses the reduction of Th1 cell-produced IL-2 levels and the increase of Th2 cell-derived IL-10 levels.
• In Vitro:
  In vitro, SB273005 inhibits human osteoclast-mediated bone resorption with IC50 of 11 nM. In blood containing MDA-MB-231 cells, a combination of SB273005 and lamifiban inhibits tumor cell adhesion to vascular extracellular matrix (ECM).

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Integrin, SB 273005, SB273005, SB-273005, αVβ3 integrin, αVβ5 integrin

Compound Identifiers

PubChem CID

9868426