SB-334867 free base

SKU: orb1301040

Description

SB-334867 free base is a selective orexin-1 (OX1) receptor antagonist with a pKi of 7.17 for the human OX1 receptor. It is widely used in research to investigate orexin signaling in sleep/wake regulation, addiction, and stress responses, employing both in vitro cellular assays and in vivo behavioral models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 792173-99-0
• MW: 319.32
• Purity: >99.99% (May vary between batches)
• Formula: C₁₇H₁₃N₅O₂
• SMILES: N(C(NC=1C=C2C(=CC1)N=C(C)O2)=O)C=3C4=C(N=CC3)C=CC=N4
• Target: OX Receptor
• Solubility: DMSO:31.9 mg/mL (99.9 mM);Ethanol:3.2 mg/mL (10.02 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.26 mM)

Bioactivity

• Target IC50:
  OXA:10 nM|OX1:40 nM|OXB:100 nM
• In Vivo:
  In both male and female rats, SB-334867 (30 mg/kg, i.p.) significantly reduces natural and orexin-A-induced food intake. SB-334867 (2 mg/kg, i.v.) blocks the effects of antipsychotic drugs on dopamine neuronal activity in rats.
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• In Vitro:
  In CHO-OX1 cells, SB-334867 inhibits the orexin-A (10 nM) and orexin-B (100 nM)-induced calcium responses with pKB of 7.27 and 7.23 respectively, without effect on the UTP (3 microM)-induced calcium response.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

activity, BEC, cell, CHO, locomotor, inhibit, Orexin Receptor (OX Receptor), OX Receptor, OX1, Hypocretin Receptor, Inhibitor, intake, HCRT Receptor, ethanol, sucrose, SB 334867, SB 334867 free base, SB334867, SB-334867, SB334867 free base, SB-334867 free base, SB334867A, SB334867A free base, OXReceptor

Compound Identifiers

PubChem CID

6604926