SB 239063

SKU: orb1300296

Description

SB 239063 is a potent and selective inhibitor of p38 MAPK α and β isoforms, exhibiting an IC50 of 44 nM with no significant activity against the γ and δ isoforms. It is widely used in research to investigate inflammation, cellular stress responses, and cytokine signaling in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 193551-21-2
• MW: 368.4
• Purity: 99.81%
• Formula: C₂₀H₂₁FN₄O₂
• SMILES: COc1nccc(n1)-c1c(ncn1[C@H]1CC[C@H](O)CC1)-c1ccc(F)cc1
• Target: p38 MAPK,Autophagy
• Solubility: DMSO:3.7 mg/mL (10.04 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.71 mM)

Bioactivity

• Target IC50:
  p38β:44 nM|p38α:44 nM
• In Vivo:
  In both guinea pigs and mice, SB 239063 (10 mg/kg, p.o.) reduces antigen-induced airway eosinophilia. In air- and ozone-exposed C57/BL6 and MKP-1(-/-) mice, SB239063 inhibits bronchial contraction.
• In Vitro:
  SB 239063 potently inhibits IL-1 and TNF-α production in LPS-stimulated human peripheral blood monocytes with IC50 of 120 and 350 nM, respectively. In oxygen-glucose-deprived hippocampal slice cultures, SB239063 strikingly reduces the levels of the pro-inflammatory cytokine IL-1beta, causes cell death after oxygen-glucose deprivation and significantly diminishes microglia activation. In human corneal endothelial cell, SB 239063 inhibits TGF-β(2) and FGF-2-induced cell migration.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophagy, Inhibitor, inhibit, p38 MAPK, p38MAPK, p38β, p38α, SB239063, SB-239063, SB 239063

Compound Identifiers

PubChem CID

5166