SB-218078

SKU: orb1706659

Description

SB-218078 is a potent, ATP-competitive, and cell-permeable inhibitor of checkpoint kinase 1 (Chk1), inhibiting cdc25C phosphorylation with an IC50 of 15 nM. It shows weaker activity against Cdc2 and PKC. This inhibitor is widely used in vitro to study DNA damage response, cell cycle checkpoint mechanisms, and as a potential chemosensitizer in cancer research.

Research Area

Cell Biology, Epigenetics & Chromatin, Signal Transduction

Key Properties

• CAS Number: 135897-06-2
• MW: 393.39
• Formula: C₂₄H₁₅N₃O₃
• SMILES: O=C1NC(=O)c2c1c1c3ccccc3n3C4CCC(O4)n4c5ccccc5c2c4c13
• Target: PKC,Apoptosis,Chk,CDK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

3387354