SB 204990

SKU: orb1218746

Description

SB 204990 is an effective and specific ATP citrate lyase enzyme inhibitor.

Key Properties

• CAS Number: 154566-12-8
• MW: 389.27
• Purity: >98% (HPLC)
• Formula: C₁₈H₂₂Cl₂O₅
• SMILES: O[C@](CC(O)=O)(C[C@@H](CCCCCCc(ccc(Cl)c1)c1Cl)O1)C1=O
• Target: ATPase
• Solubility: DMSO:100 mg/mL (256.89 mM);H2O:10 mg/mL (25.69 mM; Need ultrasonic)

Bioactivity

• In Vivo:
  SB 204990, when administered orally to rats, is absorbed into the systemic circulation. When administered in the diet (0.05-0.25%, w/w) for 1 week, SB 204990 causes a dose-related decrease in plasma cholesterol (by up to 46%) and triglyceride levels (by up to 80%) in rats. SB 204990 (25 mg/kg per day) also decreases plasma cholesterol levels (by up to 23%) and triglyceride levels (by up to 38%) in the dog, preferentially decreasing low-density lipoprotein compared with high-density lipoprotein cholesterol levels.
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• In Vitro:
  SB204990 (SB) is a specific inhibitor of ACLY enzyme. SB204990 treatment leads to a decrease in cytosolic Ac-CoA level and is thus expected to decrease acetylated and active β-catenin levels.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

ATPase