SB 202190 hydrochloride

SKU: orb1694481

Description

SB 202190 hydrochloride

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 350228-36-3
• MW: 367.8
• Purity: 99.99%
• Formula: C₂₀H₁₅ClFN₃O
• SMILES: Cl.FC=1C=CC(=CC1)C=2NC(=NC2C=3C=CN=CC3)C=4C=CC(O)=CC4
• Target: Apoptosis,p38 MAPK,Autophagy
• Solubility: DMF:10 mg/mL (27.19 mM);DMSO:60 mg/mL (163.13 mM);Ethanol:PBS (pH 7.2) (1:10):< 1 mg/mL, insoluble;Ethanol:10 mg/mL (27.19 mM)

Bioactivity

• Target IC50:
  p38β2:100 nM IC50 |p38α:50 nM IC50
• In Vivo:
  Methods: SB 202190 hydrochloride (dissolved in 100% DMSO and then diluted with normal saline (NS) to a final DMSO concentration of 0.1%, injected intracerebroventricularly) was administered to rats, and bot the VaD model group an the sham operation group received an equal volume of 0.1% DMSO injected ICV. Eight rats in Each group were examined in the Morris water maze to assess spatial learning and memory, Six rats were sacrificed and brain sections were prepared for TUNEL staining and Bcl-2/caspase-3 immunohistochemistry, and Six rats were sacrificed and tissue homogenates were prepared for Western blot assay of phosphorylated p38 MAPK expression. Results: Compared wit the model group the SB 202190 hydrochloride group showed a significantly shorter escape latency in the Morris water maze hidden platform test; compared with VaD model rats the SB 202190 hydrochloride group also showed significantly reduced hippocampal neuronal apoptosis (P < 0.01) as well as higher (anti-apoptotic) Bcl-2 expression and lower (pro-apoptotic) caspase-3 expression.
• In Vitro:
  Methods: SB 202190 hydrochloride (0-10 μM, 0-72 hours) was used to treat a subset of colorectal cancer (CRC) cell lines (RKO, CACO2, and SW480), and cell growth was measured. Results: SB 202190 hydrochloride inhibite the growth of a subset of colorectal cancer (CRC) cell lines in a dose- and time-dependent manner.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

SB 202190 HCl, SB 202190 hydrochloride, SB202190 Hydrochloride, SB-202190 Hydrochloride

Compound Identifiers

PubChem CID

135451580