SB 202190 hydrochloride

SKU: orb1694481

Description

SB 202190 hydrochloride is the salt form of the selective p38 MAPK inhibitor SB 202190. This cell-permeable compound inhibits p38α and p38β2 isoforms and has been utilized in vitro to study inflammation, apoptosis, and cardiomyocyte differentiation from stem cells, as well as in vivo tumor models.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 350228-36-3
• MW: 367.8
• Formula: C₂₀H₁₅ClFN₃O
• SMILES: [H].Cl.Oc1ccc(cc1)-c1nc(c([nH]1)-c1ccncc1)-c1ccc(F)cc1
• Target: Others
• Solubility: DMF:10 mg/mL (27.19 mM);DMSO:60 mg/mL (163.13 mM);Ethanol:PBS (pH 7.2) (1:10):< 1 mg/mL, insoluble;Ethanol:10 mg/mL (27.19 mM)

Bioactivity

• Target IC50:
  p38β2:100 nM (IC50)|p38α:50 nM (IC50)
• In Vivo:
  Methods: SB 202190 hydrochloride (dissolved in 100% DMSO and then diluted with normal saline (NS) to a final DMSO concentration of 0.1%, injected intracerebroventricularly) was administered to rats, and both the VaD model group and the sham operation group received an equal volume of 0.1% DMSO injected ICV. Eight rats in each group were examined in the Morris water maze to assess spatial learning and memory, six rats were sacrificed and brain sections were prepared for TUNEL staining and Bcl-2/caspase-3 immunohistochemistry, and six rats were sacrificed and tissue homogenates were prepared for Western blot assay of phosphorylated p38 MAPK expression. Results: Compared with the model group, the SB 202190 hydrochloride group showed a significantly shorter escape latency in the Morris water maze hidden platform test; compared with VaD model rats, the SB 202190 hydrochloride group also showed significantly reduced hippocampal neuronal apoptosis (P < 0.01) as well as higher (anti-apoptotic) Bcl-2 expression and lower (pro-apoptotic) caspase-3 expression.
  Read more...
• In Vitro:
  Methods: SB 202190 hydrochloride (0-10 μM, 0-72 hours) was used to treat a subset of colorectal cancer (CRC) cell lines (RKO, CACO2, and SW480), and cell growth was measured. Results: SB 202190 hydrochloride inhibited the growth of a subset of colorectal cancer (CRC) cell lines in a dose- and time-dependent manner.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SB 202190 HCl, SB 202190 hydrochloride, SB202190 Hydrochloride, SB-202190 Hydrochloride

Compound Identifiers

PubChem CID

135451580