SAX-187

SKU: orb1304450

Description

SAX-187 is a potent and selective ligand for the human serotonin 5-HT6 receptor. It is a valuable tool compound for investigating the receptor's function in neuropharmacology, supporting both in vitro binding assays and in vivo behavioral studies related to cognitive disorders.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 554403-49-5
• MW: 380.87
• Purity: 98.00% (May vary between batches)
• Formula: C₁₅H₁₃ClN₄O₂S₂
• SMILES: NCCc1cn(c2ccccc12)S(=O)(=O)c1c(Cl)nc2sccn12
• Target: 5-HT Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.25 mM);DMSO:60 mg/mL (157.53 mM)

Bioactivity

• Target IC50:
  5-HT6 receptor:2.2 nM (Ki)|5-HT6 receptor:6.6 nM (EC50)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Serotonin Receptor, WAY 181187, WAY181187, WAY-181187, related, SAX 187, SAX187, 5-HT Receptor, 5-HT6, 5HTReceptor, 5HT Receptor, 5-hydroxytryptamine Receptor, anxiety, cAMP, disorders, ERK1/2, Fyn, Inhibitor, OCD, inhibit

Compound Identifiers

PubChem CID

10150497