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SARS-CoV-IN-5
Catalog Number: orb2664654
| Catalog Number | orb2664654 |
|---|---|
| Category | Small Molecules |
| Description | SARS-CoV-IN-5 (compound 49) is a high-selectivity, non-peptide, non-covalent 3CLpro inhibitor. It exhibits IC50 values of 38 nM, 21.1 nM, and 86 nM against the 3CLpro of SARS-CoV-1, SARS-CoV-2, and bat coronavirus WIV1, respectively. SARS-CoV-IN-5 inhibits the replication of the SARS-CoV-2 Delta variant with an EC50 of 0.272 μM. The compound notably reduces viral copy numbers in the lungs of K18-hACE2 transgenic mouse model. Furthermore, SARS-CoV-IN-5 demonstrates broad-spectrum antiviral activity against SARS-CoV-1, WIV1, MERS, HCoV-OC43, HCoV-229E, and HKU9, targeting these coronaviruses effectively. |
| Purity | 98.00% |
| Storage | -20°C |
| Note | For research use only |
