SAR7334 hydrochloride

SKU: orb1309124

Description

SAR7334 hydrochloride is a potent and selective TRPC6 channel inhibitor with an IC50 of 7.9 nM. This compound is a valuable research tool for investigating TRPC6-mediated signaling in cardiovascular and renal diseases, applicable in both in vitro and in vivo experimental models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1333207-63-8
• MW: 440.79
• Purity: 99.18% (May vary between batches)
• Formula: C₂₁H₂₄Cl₃N₃O
• SMILES: Cl.Cl.N[C@@H]1CCCN(C1)[C@@H]1Cc2ccccc2[C@H]1Oc1ccc(cc1Cl)C#N
• Target: TRP/TRPV Channel,Others
• Solubility: DMSO:100 mg/mL (226.87 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (9.07 mM)

Bioactivity

• Target IC50:
  TRPC6 current:7.9 nM
• In Vivo:
  In isolated perfused lungs from mice, SAR7334 (10 mg/kg, p.o.) inhibits TRPC6-dependent acute HPV. it is suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR).
• In Vitro:
  SAR7334 inhibits TRPC6, TRPC3, and TRPC7-mediated Ca2+ influx into cells (IC50s of 9.5, 282, and 226 nM, respectively) , while TRPC4 and TRPC5-mediated Ca2+ entry remains unaffected. At 1 μM, SAR7334 significantly blocks Ang II-evoked calcium influx in podocytes . SAR7334 dose-dependently reduces TRPC6 currents with an IC50 of 7.9 nM, and at 100 nM, it substantially reduces TRPC6 currents .

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SAR 7334 Hydrochloride, SAR7334 Hydrochloride, SAR7334 hydrochloride, SAR-7334 Hydrochloride, SAR-7334 hydrochloride, TRPC6 currents

Compound Identifiers

PubChem CID

78357800