SAR405

SKU: orb1309129

Description

SAR405

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1523406-39-4
• MW: 443.85
• Purity: 99.99% (May vary between batches)
• Formula: C₁₉H₂₁ClF₃N₅O₂
• SMILES: C[C@@H]1COCCN1c1cc(=O)n2CC[C@H](N(Cc3cncc(Cl)c3)c2n1)C(F)(F)F
• Target: Autophagy,PI3K
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.51 mM);DMSO:27 mg/mL (60.83 mM)

Bioactivity

• Target IC50:
  Autophagy:|VPS34:1.2 nM|VPS34:1.5 nM (kd)
• In Vitro:
  SAR405, a low molecular mass kinase inhibitor of PIK3C3, highly potent and selective with regard to other lipid and protein kinases. Inhibiting the catalytic activity of PIK3C3 disrupts vesicle trafficking from late endosomes to lysosomes. SAR405 treatment also inhibits autophagy induced either by starvation or by MTOR (mechanistic target of rapamycin) inhibition. SAR405 prevents autophagosome formation (IC50: 42 nM). Treatment of starved cells with SAR405 fully inhibits the conversion to LC3-II in a dose-dependent manner. The GFP-LC3 model is used for the HTS and confirmed its activity on starved cells (IC50=419 nM) .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophagy, Inhibitor, inhibit, SAR405, SAR-405, SAR 405, Phosphoinositide 3-kinase, PI3K, Vps34

Compound Identifiers

PubChem CID

72709209