SAR156497

SKU: orb1738368

Description

SAR156497 is a highly potent and selective pan-Aurora kinase inhibitor (IC50: 0.5-3 nM) demonstrating robust in vitro antiproliferative activity and in vivo target modulation. It effectively induces polyploidy and modulates biomarkers like pHH3, making it a valuable chemical probe for cancer research, particularly in studying mitosis and kinase signaling pathways.

Research Area

Cell Biology, Epigenetics & Chromatin, Metabolism Research

Key Properties

• CAS Number: 1256137-14-0
• MW: 468.5
• Formula: C₂₇H₂₄N₄O₄
• SMILES: O=C1C=2[C@H](C=3C(=C(C(OCC)=O)NC3)NC2CCC1)C4=CC(OC=5NC=6C(N5)=CC=CC6)=CC=C4
• Target: PDE,Others,Aurora Kinase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

49787166