Saponarin

SKU: orb1684240

Description

Saponarin (Petrocomoside) demonstrates hepatoprotective and antioxidant effects in both in vitro and in vivo models, specifically against carbon tetrachloride (CCl4)-induced hepatic injury. This flavonoid glucoside is a valuable research tool for studying liver protection mechanisms, oxidative stress, and phytotherapeutic interventions in pharmacology and toxicology.

Research Area

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Metabolism Research, Neuroscience, Signal Transduction

Key Properties

• CAS Number: 20310-89-8
• MW: 594.52
• Purity: 98.84% (May vary between batches)
• Formula: C₂₇H₃₀O₁₅
• SMILES: OC[C@H]1O[C@@H](Oc2cc3oc(cc(=O)c3c(O)c2[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)-c2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
• Target: Interleukin,PERK,p38 MAPK,ERK,NF-κB,Cytochromes P450,AMPK,COX
• Solubility: DMSO:90 mg/mL (151.38 mM)

Bioactivity

• In Vitro:
  In freshly isolated rat hepatocytes, paracetamol (100 μ mol) led to a significant decrease in cell viability, increased LDH leakage, decreased levels of cellular GSH, and elevated MDA quantity. Saponarin (60-0.006 μ g/mL) preincubation, however, significantly ameliorated paracetamol-induced hepatotoxicity in a concentration-dependent manner. The beneficial effect of Saponarin was also observed in vivo. Rats were challenged with paracetamol alone (600 mg/kg, i.p.) and after 7-day pretreatment with Saponarin (80 mg/kg, oral gavage). Paracetamol toxicity was evidenced by increase in MDA quantity and decrease in cell GSH levels and antioxidant defence system. No changes in phase I enzyme activities of AH and EMND and cytochrome P 450 quantity were detected. Saponarin pretreatment resulted in significant increase in cell antioxidant defence system and GSH levels and decrease in lipid peroxidation. The biochemical changes are in good correlation with the histopathological data. Protective activity of Saponarin was similar to the activity of positive control silymarin.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Isovitexin-7-O-glucoside, P450, NFκB, NF-κB, NFkB, NF-kB, ERK, Petrocomoside, Saponaretin-7-O-glucoside, Saponarin

Compound Identifiers

PubChem CID

441381