Sanofi Lipid VII

SKU: orb3033122

Description

Lipid VII is a novel ionizable cationic lipid developed by Sanofi.Lipid VII demonstrates exceptional performance as a lipid nanoparticle delivery system, combining high efficiency with outstanding safety. Cellular assays reveal VII achieves 180,000 RLU transfection efficiency under serum conditions, surpassing traditional SS-OP systems by 2.25-fold while maintaining perfect 100% cellular viability and eliminating cytotoxicity risks that plague alternatives. In vivo systemic delivery shows rapid whole-body biodistribution, reaching photon emission levels exceeding 1.00E+10 photons/sec within 48 hours. VII exhibits superior organ targeting with a liver-specific accumulation ratio of 9.0, outperforming SS-OP systems by 50%, while reducing off-target spleen accumulation by 20%. Its versatility is further validated in therapeutic protein expression, where structural analogs achieve erythropoietin concentrations of 14 ng/mL, exceeding industry standards by 180%. For vaccine applications, VII generates a median HAI titer of 7,611 against H1N1 influenza—540 times higher than baseline buffers and more than double the next-best formulation. This evidence establishes VII as a breakthrough technology, offering unmatched efficiency, precision targeting, and clinical-grade safety across diverse applications.

Research Area

Metabolism Research

Key Properties

• MW: 1154.79
• Purity: >95%
• Formula: C₆₈H₁₃₁O₁₂N
• SMILES: CCCCCCCCC(CCCCCCCC)OC(=O)CCCCCCCOCC(COCCOCCOCCOCCOC(=O)C1CCN(C)CC1)OCCCCCCCC(=O)OC(CCCCCCCC)CCCCCCCC

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only