Sanggenone C

SKU: orb1221769

Description

Sanggenone C inhibits tumor cellular proteasomal activity and cell viability, via induction of cell cycle arrest and cell death , inhibiting the proteasome function. Sanggenone C and O inhibited NO production and iNOS expression by suppressing NF-κB activity and IκBα activation; inhibited TNF-alpha -stimulated PMN-HSC adhesion and expression of VCAM-1 by suppressing the activation of NF-kappaB.

Key Properties

• CAS Number: 80651-76-9
• MW: 708.71
• Purity: >98% (HPLC)
• Formula: C₄₀H₃₆O₁₂
• SMILES: CC1=CC(C(C(C1)C2=C(C=C(C=C2)O)O)C(=O)C3=C(C=C(C=C3)O)O)C4=C(C=C5C(=C4O)C(=O)C6(C(O5)(C7=C(O6)C=C(C=C7)O)CC=C(C)C)O)O
• Target: Antibacterial
• Solubility: In Vitro: DMSO : 100 mg/mL (141.10 mM)

Bioactivity

• In Vivo:
  Animal model: Male C57/BL6 mice (weight 23.5-27.5 g; age, 8 weeks). Dosage: 10, 20 mg/kg. Administration: Intraperitoneally; daily; for 3 weeks. Result: Prevented the development of ventricular dysfunction, as evidenced by decreased LV end-diastolic diameter, LV end-systolic diameter, and increased LVFS and LVEF.
• In Vitro:
  Cell Proliferation Assay Cell line: Human GC cell lines HGC-27 and AGS cells. Concentration: 4-12 μM. Incubation time: 24 h. Result: Inhibited the proliferation of GC cells in a dose-dependent manner. The IC50 values of were 9.129 μM for HGC-27 and 9.863 μM for AGS. Cell Cycle Analysis Cell line: Human GC cell lines HGC-27 and AGS cells. Concentration: 6, 8, 10 μM. Incubation time: 24 h. Result: The proportions of cells in the G0-G1 phase were increased and the levels of CDK4 and cyclin D1 were decreased. Apoptosis Analysis Cell line: Human GC cell lines HGC-27 and AGS cells. Concentration: 6, 8, 10 μM. Incubation time: 24 h. Result: Exhibited a dose-dependent induction of apoptosis, with the percentage of apoptotic cells increasing from 7.3% to 24.8% and from 4.6% to 15.1% for HGC-27 and AGS cells, respectively. Western blot analysis. Cell line: Human GC cell lines HGC-27 and AGS cells. Concentration: 6, 8, 10 μM. Incubation time: 24 h. Result: The levels of p-ERK were markedly downregulated.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Sanggenone C | Sanggenon C

Quick Database Links

Gene Symbol

Antibacterial