Salvianolic acid B

SKU: orb1305104

Description

Salvianolic acid B

Key Properties

• CAS Number: 115939-25-8
• MW: 718.59
• Purity: 99.86%
• Formula: C₃₆H₃₀O₁₆
• SMILES: OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c1ccc(O)c2O[C@@H]([C@@H](C(=O)O[C@H](Cc3ccc(O)c(O)c3)C(O)=O)c12)c1ccc(O)c(O)c1
• Target: Others
• Solubility: DMSO:91 mg/mL (126.64 mM)

Bioactivity

• In Vivo:
  METHODS: To investigat the effects of peripheral arterial disease (PAD), Salvianolic acid B (15 mg/kg) was intraperitoneally injected once daily for 12 days into a hindlimb ischemia mouse model. RESULTS the Salvianolic acid B group showed significant improvement in blood perfusion, capillary density, musclee edema and M2 marker gene expression. Salvianolic acid B had a Protective effect in PAD and enhanced macrophage polarization throug the SIRT1/PI3K/AKT pathway.
• In Vitro:
  METHODS: Human lung cancer cell lines NCI-H2030 and NCI-H1650 were treated with Salvianolic acid B (100-600 µM) for 24-48 h. Cell viability was measured by CCK-8 assay. Results: At 24 h of exposure the cell viability of NCI-H2030 and NCI-H1650 cells was significantly reduced whe the concentration of Salvianolic acid B reached 400 µM. At 48 h exposure the cell viability was significantly reduced unti the concentration reached 300 µM, which was significantly higher than that o the control group. METHODS: Human renal proximal tubule cells HK-2 were treated with TGF-β1 (2.5 ng/mL) and Salvianolic acid B (1-10 µM) for 24 h. Gene expression levels were measured by RT-PCR. Results: TGF-β1 significantly inhibite the expression of E-cadherin mRNA in HK-2 cells, while 1-10 µM Salvianolic acid B prevente the loss of its expression.

Storage & Handling

• Storage: keep away from direct sunlight,The compound is unstable in solution. Please use soon | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Salvianolic acid B, T2727, 121521-90-2

Compound Identifiers

PubChem CID

6451084