Salvianolic acid A

SKU: orb1300252

Description

Salvianolic acid A

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 96574-01-5
• MW: 494.45
• Purity: 99.98%
• Formula: C₂₆H₂₂O₁₀
• SMILES: OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c1ccc(O)c(O)c1\C=C\c1ccc(O)c(O)c1
• Target: MMP
• Solubility: 10% DMSO+90% Saline:13 mg/mL (26.29 mM);DMSO:85 mg/mL (171.91 mM);Ethanol:10 mg/mL (20.22 mM)

Bioactivity

• In Vivo:
  METHODS: In order to investigat the effects on amnesia in mice, Salvianolic acid A (10-40 mg/kg) was administered orally once daily for five days to a C57BL/6 mouse model of amnesia induced by diazepam. Results: Salvianolic acid A exerts an antiamnesic effect on diazepam-induced paracrine amnesia in mice by enhancin the antioxidant capacity o the hippocampus.
• In Vitro:
  METHODS: Five tumor cell lines, SKOV3, HeLa, NCI-H1975, DU145 and A549, were treated with Salvianolic acid A (1.56-100 µM) for 72 h. Cell viability was measured by CellTiter-Glo kit. Results the growth of SKOV3, HeLa, NCI-H1975, DU145 and A549 cells was inhibited with increasing concentration of Salvianolic acid A, with IC50 of 30.84 µM, 15.85 µM, 10.19 µM, 9.512 µM and 6.461 µM, respectively METHODS: Rat cardiomyocytes H9C2 were treated with Salvianolic acid A (50 µM) and Doxorubicin (4 µM) for 12 h. Apoptosis was detected by TUNEL assay. Results the number of apoptotic cells increased significantly after Dox stimulation. H9C2 cells co-treated with Dox and Salvianolic acid A exhibited significantly lower apoptosis rates compared to cells exposed to Dox. Salvianolic acid A inhibited Dox-induced apoptosis in H9C2 cells.

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Dan Phenolic Acid A, Inhibitor, Matrix metalloproteinases, inhibit, MMP, MMP-9, Salvianolic acid A

Compound Identifiers

PubChem CID

5281793