Salvianolic acid A

SKU: orb1300252

Description

Salvianolic acid A is a natural MMP-9 inhibitor with demonstrated antioxidant and anti-inflammatory properties. Research applications include studying its neuroprotective effects and blood-brain barrier integrity in models of cerebral ischemia and other neurological disorders.

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 96574-01-5
• MW: 494.45
• Purity: >99.99% (May vary between batches)
• Formula: C₂₆H₂₂O₁₀
• SMILES: OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c1ccc(O)c(O)c1\C=C\c1ccc(O)c(O)c1
• Target: MMP
• Solubility: 10% DMSO+90% Saline:13 mg/mL (26.29 mM);DMSO:85 mg/mL (171.91 mM);Ethanol:10 mg/mL (20.22 mM)

Bioactivity

• In Vivo:
  METHODS: In order to investigate the effects on amnesia in mice, Salvianolic acid A (10-40 mg/kg) was administered orally once daily for five days to a C57BL/6 mouse model of amnesia induced by diazepam. RESULTS: Salvianolic acid A exerts an antiamnesic effect on diazepam-induced paracrine amnesia in mice by enhancing the antioxidant capacity of the hippocampus.
• In Vitro:
  METHODS: Five tumor cell lines, SKOV3, HeLa, NCI-H1975, DU145 and A549, were treated with Salvianolic acid A (1.56-100 µM) for 72 h. Cell viability was measured by CellTiter-Glo kit. RESULTS: The growth of SKOV3, HeLa, NCI-H1975, DU145 and A549 cells was inhibited with increasing concentrations of Salvianolic acid A, with IC50s of 30.84 µM, 15.85 µM, 10.19 µM, 9.512 µM and 6.461 µM, respectively. METHODS: Rat cardiomyocytes H9C2 were treated with Salvianolic acid A (50 µM) and Doxorubicin (4 µM) for 12 h. Apoptosis was detected by TUNEL assay. RESULTS: The number of apoptotic cells increased significantly after Dox stimulation. H9C2 cells co-treated with Dox and Salvianolic acid A exhibited significantly lower apoptosis rates compared to cells exposed to Dox. Salvianolic acid A inhibited Dox-induced apoptosis in H9C2 cells.

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Dan Phenolic Acid A, Inhibitor, Matrix metalloproteinases, inhibit, MMP, MMP-9, Salvianolic acid A

Compound Identifiers

PubChem CID

5281793