Salicylate choline

SKU: orb3173106

Description

Salicylate choline is a derivative of Aspirin (acetylsalicylic acid) and is orally active. It significantly reduces the levels of IL-1β, IL-6, TNF-α, and IL-10 in cells. By inducing S phase cell cycle arrest and impairing DNA damage repair, salicylate choline enhances the antitumor activity of the CRM1 inhibitor Selinexor (KPT-330). When combined with Selinexor, salicylate choline demonstrates excellent antitumor efficacy in mouse xenograft models with JeKo-1 cells. It is applicable in the research of rheumatism, inflammation, and cancer.

Research Area

Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 2016-36-6
• MW: 241.29
• Formula: C₁₂H₁₉NO₄
• SMILES: O=C([O-])C=1C=CC=CC1O.OCC[N+](C)(C)C
• Target: Interleukin,PLK,TNF

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

Interleukin,PLK,TNF