Salermide

SKU: orb1303521

Description

Salermide is a selective Sirt1 and Sirt2 inhibitor that induces potent, cancer-selective apoptosis. This small molecule is a valuable research tool for studying sirtuin biology in oncology, with applications in both in vitro cell culture models and in vivo xenograft studies.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 1105698-15-4
• MW: 394.47
• Purity: 97.62%
• Formula: C₂₆H₂₂N₂O₂
• SMILES: CC(C(=O)Nc1cccc(c1)\N=C\c1c(O)ccc2ccccc12)c1ccccc1
• Target: Sirtuin,Apoptosis
• Solubility: 10% DMSO+90% Corn Oil:2 mg/mL (5.07 mM);DMSO:45 mg/mL (114.08 mM)

Bioactivity

• In Vivo:
  Salermide is well tolerated by mice at concentrations up to 100 μM, with no adverse health effects observed in terms of diet consumption, body-weight gain, or postural and behavioral changes .
• In Vitro:
  Salermide prompts tumour-specific cell death in a wide range of human cancer cell lines. The antitumour activity of Salermide is primarily because of a massive induction of apoptosis. Salermide induces apoptosis in cancer but not in normal cells. It induces strong apoptosis without any evident effect on the cell cycle in all the cancer cell lines analysed except in non-tumorigenic MRC5 cells. The induction of apoptosis is cell-type-specific and dose-dependent.
• Cell Research:
  Cell viability is determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay as described earlier. IC50 index is calculated using four Salermide concentrations (25, 50, 75 and 100 μm) for 24 h. The percentage of apoptotic cells is determined with the FACSCalibur apparatus.(Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, Inhibitor, inhibit, Salermide, Sirtuin, SIRT1, SIRT2

Compound Identifiers

PubChem CID

135659046