SAL-0010042

SKU: orb2945555

Description

SAL-0010042 is a potent inhibitor of Plasmodium PDEβ (IC50=48.9 nM), blocking cAMP/cGMP hydrolysis to activate PKG and inhibit parasite growth (IC50s: 142 nM 3D7, 218 nM Dd2). It also inhibits human PDE5 and PDE6. This compound is a valuable tool for studying cyclic nucleotide signaling in malaria parasite biology and transmission.

Research Area

Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 521298-46-4
• MW: 286.304
• Formula: C₁₅H₁₅FN₄O
• SMILES: O=C1N=C(NC=2C(=NNC12)C(C)C)CC=3C=CC=CC3F
• Target: PDE,Parasite

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

135721129