SAHM1

SKU: orb1679236

Description

This stabilized, hydrocarbon-stapled alpha-helical peptide acts as a Notch pathway inhibitor by targeting the protein-protein interaction interface to disrupt complex assembly. It is a valuable tool for probing Notch signaling in cancer and developmental biology research, with utility in both cellular and in vivo models.

Research Area

Neuroscience, Protein Biochemistry, Stem Cell & Developmental Biology

Key Properties

• Target: Gamma-secretase
• CAS Number: 2050906-89-1
• MW: 2196.58
• Formula: C₉₄H₁₆₂N₃₆O₂₃S
• SMILES: [C@H](CC1=CN=CN1)(C(N[C@@H](CC2=CN=CN2)C(N[C@H](C(N[C@@H]([C@@H](C)O)C(O)=O)=O)CO)=O)=O)NC(=O)[C@@]3(C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC(=O)[C@@](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CCNC(C)=O)=O)CCC(O)=O)=O)CCCNC(=N)N)=O)CC(C)C)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)[C@H](CC)C)=O)(C)CCCC=CCCC3

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

176418250