SAH-SOS1A

SKU: orb1679237

Description

This small molecule inhibitor disrupts the KRas-SOS1 interaction by binding the KRas nucleotide pocket (Kd 106-176 nM), blocking nucleotide exchange and downstream ERK-MAPK signaling. It exhibits cell permeability and cytotoxicity in KRas-driven cancer models, supporting its use in oncology research for both in vitro and in vivo studies of Ras pathway dysregulation.

Research Area

Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• Target: Kras,Ras
• CAS Number: 1652561-87-9
• MW: 2187.53
• Formula: C₁₀₀H₁₅₉N₂₇O₂₈
• SMILES: [C@H](CC1=CC=CC=C1)(C(N[C@@H](CC2=CC=CC=C2)C(NCC(N[C@H](C(N[C@]3(C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@]([C@@H](C)O)(C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CC(N)=O)C(O)=O)=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)[C@@H](C)O)=O)CCCCN)=O)CC(C)C)=O)(C)CCCC=CCCC3)[H])=O)[C@H](CC)C)=O)=O)=O)NC([C@@H](NC([C@H](CCCNC(=N)N)NC(C)=O)=O)CCCNC(=N)N)=O

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

146018958