SAH-EZH2

SKU: orb1679238

Description

This small molecule inhibitor disrupts the EZH2/EPP interaction with a Kd of 320 nM, leading to reduced EZH2 expression and H3K27me3 by the PRC2 complex. It halts proliferation and promotes monocyte-to-macrophage differentiation in MLL-AF9 leukemia models, supporting research into epigenetic therapies for hematological cancers.

Research Area

Epigenetics & Chromatin, Metabolism Research; Epigenetics & Chromatin

Key Properties

• Target: Histone Methyltransferase
• CAS Number: 1453222-26-8
• MW: 3432.05
• Formula: C₁₅₅H₂₅₆N₄₈O₄₀
• SMILES: C([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@@]1(C)NC(=O)[C@H](CC(C)C)NC(=O)[C@]([C@H](CC)C)(NC(=O)[C@H](CCCCN)NC(=O)[C@](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC2=CC=CC=C2)NC(C)=O)=O)CO)=O)CO)=O)CC(N)=O)=O)CCCNC(=N)N)=O)(C)CCCC=CCCC1)[H])CCCNC(=N)N)=O)[C@@H](C)O)=O)CCC(N)=O)=O)[C@H](CC)C)=O)CC(C)C)=O)CC(N)=O)=O)CCC(N)=O)=O)CCC(O)=O)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(=O)N3[C@H](C(N[C@@H](C(C)C)C(O)=O)=O)CCC3)CCC(N)=O)=O)[C@H](CC)C)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCC(N)=O)=O)CCCCN)=O)C=4C=5C(NC4)=CC=CC5

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

176418251