Safranal

SKU: orb1297151

Description

Safranal, the principal volatile compound responsible for saffron's aroma, exhibits neuroprotective and anti-inflammatory properties. It is utilized in Parkinson's disease research, with studies demonstrating its effects in both in vitro models and in vivo animal studies related to neurodegeneration.

Research Area

Immunology & Inflammation, Metabolism Research

Key Properties

• CAS Number: 116-26-7
• MW: 150.22
• Purity: 96.33% (May vary between batches)
• Formula: C₁₀H₁₄O
• SMILES: CC1=C(C=O)C(C)(C)CC=C1
• Target: Antioxidant,Nrf2
• Solubility: Ethanol:100 mg/mL (665.69 mM);DMSO:100 mg/mL (665.69 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (26.63 mM)

Bioactivity

• In Vivo:
  Safranal (200-500 mg/kg; PO; for 7 days) slightly restores colon length and reduces weight loss percentage, significantly lowering the DAI score.
• In Vitro:
  At first, the potential toxic effect of safranal on OLN-93 viability was evaluated. Also, the cells were pretreated with safranal (0.1, 1, 10, 50, 100 and 200 μM) for 2 h and then subjected to glutamic acid (16 mM) or quinolinic acid (8 mM) toxicity for 24 h, in which the same treatments were applied. Results: Safranal at concentration ranges of 1-800 μM had no toxic effect on cell viability (p>0.05). Treatment with safranal significantly increased cell viability following glutamic acid or quinolinic acid insults at concentrations higher than 1 μM (p<0.01). The cytoprotective potential of safranal was also accompanied by decreased ROS accumulation (p<0.001) and malondialdehyde level (p<0.001) following glutamic acid or quinolinic acid insults. The data suggests that safranal exhibits oligoprotection potential by means of inhibiting oxidative stress parameters.

Storage & Handling

• Storage: store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, neuroprotective, orally, Parkinson's, Antioxidant, anti-inflammatory, disease, Saffron, Safranal

Compound Identifiers

PubChem CID

61041