SAFit2

SKU: orb1706668

Description

SAFit2 is a potent and selective FKBP51 inhibitor (Ki = 6 nM) that modulates the AKT2-AS160 pathway and glucocorticoid signaling. It is a research tool for studying metabolic disorders, neuropsychiatric conditions, and chronic pain in preclinical models.

Research Area

Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 1643125-33-0
• MW: 802.99
• Purity: >99.99% (May vary between batches)
• Formula: C₄₆H₆₂N₂O₁₀
• SMILES: COc1ccc(CC[C@@H](OC(=O)[C@@H]2CCCCN2C(=O)[C@@H](C2CCCCC2)c2cc(OC)c(OC)c(OC)c2)c2cccc(OCCN3CCOCC3)c2)cc1OC
• Target: FKBP
• Solubility: DMSO:87.5 mg/mL (108.97 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (4.11 mM)

Bioactivity

• Target IC50:
  FKBP51:6 nM(ki)
• In Vivo:
  METHODS: SAFit2 (20 mg/kg, intraperitoneal injection, twice a day, 10 days) was administered to mice and glucose tolerance was observed. RESULTS SAFit2 treatment significantly improved glucose tolerance.
• In Vitro:
  METHODS: The effects of SAFit2 (1, 5, 10 μM) on macrophage migration were evaluated in a Transwell assay. RESULTS SAFit2 significantly reduced macrophage migration in a concentration-dependent manner.

Storage & Handling

• Storage: store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

FKBP51, SAFit2, SAFit-2

Compound Identifiers

PubChem CID

86277887