Safinamide

SKU: orb1685635

Description

Safinamide is a multifunctional small molecule that acts as a potent, reversible MAO-B inhibitor and glutamate release inhibitor, with additional activity on dopamine reuptake and ion channels. Its research applications include investigations for Parkinson's disease, with studies exploring its neuroprotective effects in both cellular and animal models of dopaminergic dysfunction.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 133865-89-1
• MW: 302.34
• Purity: 99.92% (May vary between batches)
• Formula: C₁₇H₁₉FN₂O₂
• SMILES: O(CC1=CC(F)=CC=C1)C2=CC=C(CN[C@H](C(N)=O)C)C=C2
• Target: Monoamine Oxidase,MAO,Sodium Channel
• Solubility: DMSO:50 mg/mL (165.38 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.62 mM)

Bioactivity

• Target IC50:
  MAO-A:580 μM|MAO-B:98 nM
• In Vivo:
  Daily intraperitoneal injections of Safinamide 1mg/kg were administered for 14 days and the treatment prior to MCAO significantly ameliorates MCAO-caused cerebral infarction volume, neurological deficit, disruption of the brain-blood barrier (BBB), and impairs expression of tight junction protein occludin and ZO-1 in mice .Safinamide (intraperitoneal injection; 5 mg/kg, 15 mg/kg and 30 mg/kg) dose dependently inhibits the veratridine-induced GABA release and Glu release in vivo .
• In Vitro:
  Safinamide (1–300 µM) reduces the amplitude of the peak sodium currents in a concentration-dependent manner. When the holding potential is depolarized to -53 mV, the inhibitory effect of safinamide with a lower IC50 value (8 µM) in rat cortical neurons .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SodiumChannel, Sodium Channel, Safinamide, MAO-B, EMD 1195686, EMD1195686, EMD-1195686, FCE 26743, FCE26743, FCE-26743

Compound Identifiers

PubChem CID

131682