Sabizabulin

SKU: orb1706482

Description

Sabizabulin is an orally active tubulin inhibitor that suppresses tumor growth and metastasis in preclinical models. It has demonstrated activity against melanoma, prostate, and cervical cancer cell lines, with research indicating it targets HPV oncoproteins E6/E7 in cervical cancer.

Research Area

Cell Biology, Infectious Disease & Virology, Signal Transduction

Key Properties

• CAS Number: 1332881-26-1
• MW: 377.39
• Purity: 99.79% (May vary between batches)
• Formula: C₂₁H₁₉N₃O₄
• SMILES: COc1cc(cc(OC)c1OC)C(=O)c1c[nH]c(n1)-c1c[nH]c2ccccc12
• Target: Virus Protease,Microtubule Associated,Apoptosis
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.3 mM);DMSO:50 mg/mL (132.49 mM)

Bioactivity

• In Vivo:
  METHODS: Sabizabulin (ABI-231) (17 mg/kg/20 mg/kg, oral, three weeks) was used to treat BT474 xenograft/HCI-12 PDX model mice and its therapeutic effect was observed. RESULTS Sabizabulin (ABI-231) significantly reduced the tumor volume and tumor wet weight of terminal BT474 xenograft mice, inhibited tumor growth and suppressed lung metastasis in HCI-12 PDX model mice.
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• In Vitro:
  METHODS: BT474 and SKBR3 cells were treated with Sabizabulin (ABI-231) (4, 8, 12, 16 nM), and cell growth inhibition was measured by MTS assay. RESULTS Sabizabulin (ABI-231) significantly inhibited the growth of BT474 and SKBR3 cells in a concentration-dependent manner with IC50 values ​​of 9.07 and 8.18 nM, respectively, and had low cytotoxicity.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ABI 231, ABI231, ABI-231, Microtubule Associated, MicrotubuleAssociated, tubulin, Tubulin, Sabizabulin, VERU 111, VERU111, VERU-111

Compound Identifiers

PubChem CID

53379371