S961

SKU: orb1983823

Description

S961 is a potent and selective insulin receptor (IR) antagonist, exhibiting high affinity for human IR isoforms A and B with IC50 values in the low nanomolar range, while showing significantly lower activity against the IGF-1R. This peptide is a valuable research tool for studying insulin signaling, insulin resistance mechanisms, and metabolic disorders in both cellular and animal models.

Research Area

Signal Transduction

Key Properties

• Target: IGF-1R
• CAS Number: 1083433-49-1
• MW: 4804.13
• Purity: 99.44% (May vary between batches)
• Formula: C₂₁₁H₂₉₇N₅₅O₇₁S₂
• SMILES: CC[C@@H]([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC(CNC([C@@H](NC(CNC(CNC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CN)=O)CO)=O)CC(C)C)=O)CC(O)=O)=O)CCC(O)=O)=O)CO)=O)CC1=CC=CC=C1)=O)CC2=CC=C(O)C=C2)=O)CC(O)=O)=O)CC3=CNC4=CC=CC=C43)=O)CC5=CC=CC=C5)=O)CCC(O)=O)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CC(C)C)=O)=O)=O)=O)CO)=O)=O)=O)CO)=O)CO)=O)CC(C)C)=O)CCC(O)=O)=O)CCC(O)=O)=O)CCC(O)=O)=O)CC6=CNC7=CC=CC=C76)=O)C)=O)CCC(N)=O)=O)C(N[C@H](C(N[C@H]8CSSC[C@@H](C(N9CCC[C@H]9C(N[C@H](C(N[C@H](C(O)=O)CC%10=CC=C(O)C=C%10)=O)CO)=O)=O)NC(CNC([C@H](CCCNC(N)=N)NC(CNC([C@H](CC%11=CNC%12=CC=CC=C%12%11)NC([C@H](C(C)C)NC([C@H](CCC(O)=O)NC8=O)=O)=O)=O)=O)=O)=O)=O)CCC(N)=O)=O)C

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

IGF-1R