S26131

SKU: orb1307761

Description

S26131 is a potent and selective melatonin receptor antagonist, exhibiting high affinity for MT1 (Ki = 0.5 nM) and lower affinity for MT2 (Ki = 112 nM). This small molecule is a valuable research tool for investigating circadian rhythms, sleep disorders, and cancer biology in both in vitro and in vivo experimental models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 296280-56-3
• MW: 498.61
• Purity: 99.77% (May vary between batches)
• Formula: C₃₁H₃₄N₂O₄
• SMILES: CC(=O)NCCc1cccc2ccc(OCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12
• Target: MT Receptor,Melatonin Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.01 mM);DMSO:25 mg/mL (50.14 mM)

Bioactivity

• Target IC50:
  MT2:112 nM(Ki)|MT1:0.5 nM(Ki)
• In Vitro:
  S26131 is an effective and selective antagonist of MT1 and MT2 with KBs of 5.32 and 143 nM, respectively.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

antagonist, ligand, MTReceptor, inhibit, MT1 receptor, MT Receptor, MT2 receptor, MT2, N-[2-[7-[3-[8-(2-acetamidoethyl)naphthalen-2-yl]oxypropoxy]naphthalen-1-yl]ethyl]acetamide, Inhibitor, Melatonin Receptor, melatoninergic, S 26131, S26131, S-26131, selectively

Compound Identifiers

PubChem CID

9870523