S1RA

SKU: orb1706403

Description

S1RA (E-52862) is a potent and highly selective sigma-1 receptor (σ1R) antagonist with a Ki of 17 nM, exhibiting over 1000-fold selectivity for σ1R versus the sigma-2 receptor (σ2R). This tool compound is widely used in vitro and in vivo to investigate σ1R function in neuropathic pain, neuroprotection, and psychiatric disorders.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 878141-96-9
• MW: 337.42
• Purity: 99.45%
• Formula: C₂₀H₂₃N₃O₂
• SMILES: Cc1cc(OCCN2CCOCC2)nn1-c1ccc2ccccc2c1
• Target: Sigma receptor,5-HT Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.93 mM);DMSO:10 mM

Bioactivity

• Target IC50:
  σ2 receptor (guinea pig):>1000 nM (Ki)|σ2 receptor (rat):9300 nM (Ki)|5-HT2B receptor (human):328 nM (Ki)|σ1 receptor:17 nM(Ki)|σ1 receptor (guinea pig):23.5 nM (Ki)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

E 52862, E52862, E-52862, Inhibitor, inhibit, σ1, S1RA, S-1RA, Sigma receptor, Sigma Receptor, Sigmareceptor

Compound Identifiers

PubChem CID

44247568