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S1PR1/S1PR5 agonist-1

SKU: orb3211467

Description

S1PR1/S1PR5 agonist-1 (Compound 19) is an orally active agonist for S1PR1 and S1PR5, with EC50 values of 40.0 and 22.9 nM, respectively. It interacts with essential residues of S1PR1 to mediate agonist activity. S1PR1/S1PR5 agonist-1 effectively alleviates colitis pathology in a DSS-induced mouse model with minimal impact on heart rate, making it useful for research in inflammatory bowel disease.

Images & Validation

Key Properties

TargetLPL Receptor

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information