S1PR1 modulator 1

SKU: orb1309134

Description

S1PR1 modulator 1 is a potent and selective S1PR1 inhibitor, exhibiting a pIC50 of 7.6. This compound is a valuable research tool for investigating S1P signaling in immunological and inflammatory processes, applicable in both cellular assays and animal disease models.

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2328109-05-1
• MW: 408.51
• Purity: 99.69% (May vary between batches)
• Formula: C₂₃H₂₄N₂O₃S
• SMILES: N(\CCC)=C\1/N(C(=O)\C(=C\C2=CC(C)=C(OC(C)=O)C=C2)\S1)C3=C(C)C=CC=C3
• Target: LPL Receptor
• Solubility: DMSO:41.26 mg/mL (101 mM)

Bioactivity

• Target IC50:
  S1P1 receptor:7.6(pIC50) |S1P3 receptor:6(pIC50)
• In Vitro:
  S1PR1 modulator 1 shows >40- and >80-fold selectivity, over the other S1PR isoforms S1PR3 (pIC50, 6), S1PR2 and S1PR4 (pIC50s, <5).

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, LPL Receptor, LPLReceptor, Lysophospholipid Receptor, S1PR1, S1PR1 modulator 1, S-1PR1 modulator 1, S1PR3

Compound Identifiers

PubChem CID

138377599