Queen's Award Received in 2021 ISO 9001 Certified Delivered over 1,000,000 bio-reagents to life science researchers Trusted by Life Science Communities
Cart summary

You have no items in your shopping cart.

S1P1 agonist 7

SKU: orb3173326

Description

S1P1 agonist 7 is a potent and orally active β-arrestin-biased S1P1 agonist [EC50 (G-protein) = 12.7 nM, EC50 (β-arrestin) = 3.23 nM], exhibiting strong immunomodulatory activity and favorable safety. It has excellent metabolic stability, shows weak to moderate CYP inhibition, and demonstrates high selectivity without affecting the S1P3 receptor. In a mouse model of experimental autoimmune encephalomyelitis, S1P1 agonist 7 shows favorable pharmacokinetic properties, effectively reduces circulating lymphocyte counts, and significantly alleviates disease severity. This compound is applicable for research in multiple sclerosis.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

TargetLPL Receptor

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Similar Products

  • D-erythro/L-threo Lysosphingomyelin (d18:1) [orb1693085]

    82970-80-7

    464.62

    C23H49N2O5P

    5 mg, 10 mg, 50 mg
  • VPC 23019 [orb1706476]

    449173-19-7

    372.4

    C17H29N2O5P

    100 mg, 250 mg, 1 g
  • VPC 23019 [orb1218018]

    >98% (HPLC)

    449173-19-7

    372.4

    C17H29N2O5P

    10 mg, 25 mg, 50 mg, 100 mg, 200 mg, 500 mg, 1 g
  • Ozanimod [orb1226580]

    >98% (HPLC)

    1306760-87-1

    404.4617

    C23H24N4O3

    10 mg, 25 mg, 50 mg, 100 mg, 200 mg, 500 mg, 1 g, 5 mg
  • Ponesimod [orb1223849]

    >98% (HPLC)

    854107-55-4

    460.9736

    C23H25ClN2O4S

    2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 1 g, 500 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Protocol Information